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Amer. Orthoptic Jrnl. 53(1):133-137 (2003); doi:10.3368/aoj.53.1.133
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Case Report: Exotropia Surgery in CPEO

Ian M. MacDonald, M.D.*,, Edward S. Johnson, M.D.** and Brad Wakeman, O.C.(C)*

Correspondence: Requests for reprints should be addressed to: Ian M. Mac-Donald, M.D., Dept. of Ophthalmology, Royal Alexandria Hospital, 10240 Kingsway Ave., Edmonton, AB, Canada T5H 3V9.

Exotropia in a patient with CPEO was managed with bilateral medial rectus resections. Molecular genetic analysis of DNA from a skeletal muscle biopsy confirmed a deletion of the mitochondrial DNA. The resected muscle tendon was subjected to transmission electron microscopy, revealing muscle fibre variability and ragged red fibres with mitochondrial abnormalities.

Key words: CPEO, exotropia, strabismus surgery, mitochondria






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